Phenytoin is the most common drug for seizures
Phenytoin has a low toxicity
Phenytoin is believed to protect against seizures by causing voltage-dependent block of voltage gated sodium channels.
This blocks sustained high frequency repetitive firing of action potentials.
The primary site of action appears to be the motor cortex where spread of seizure activity is inhibited.
Carbamazepine is a sodium channel blocker
In the UK, both clobazam and clonazepam are second-line choices for treating many forms of epilepsy.
Diazepam is a Benzodiazepine sedative
Two medications at once is recommended only if a single medication does not work.
It usually takes a couple of weeks for carbamazepine to work.